Background
Wound therapeutic is a posh physiological course of that may be compromised by an infection and impaired tissue regeneration. Typical dressings, usually made out of pure fibers reminiscent of cotton or linen, provide restricted performance. Nanofiber scaffolds, significantly these based mostly on biocompatible polymers like PLA, present excessive floor space and porosity, making them appropriate for managed drug supply and tissue interplay.
Curcumin, a bioactive compound derived from turmeric, has demonstrated anti-inflammatory and antibacterial properties. Nevertheless, its use in wound care is restricted by poor solubility and low bioavailability. CNTs provide complementary benefits: they possess intrinsic antibacterial exercise and might enhance the mechanical properties and drug launch profiles of polymer-based methods.
This research investigates the mixing of CNTs into PLA-curcumin nanofibers to create a multifunctional wound dressing able to each structural help and an infection management.
The Present Examine
The dressing was produced utilizing electrospinning, a method appropriate for fabricating nanofibers with managed morphology. PLA (molecular weight: 203,000 g/mol) was dissolved in dichloromethane, adopted by the addition of curcumin to make sure uniform dispersion. CNTs have been integrated at various concentrations to evaluate their results on the fabric’s structural and purposeful properties.
Electrospun nanofibers have been collected utilizing a normal setup with a managed stream price and stuck needle-to-collector distance. Characterization included Fourier-transform infrared spectroscopy (FTIR) for chemical evaluation and scanning electron microscopy (SEM) for morphology. Tensile checks evaluated mechanical energy, whereas curcumin launch profiles have been analyzed by means of in vitro assays. Antibacterial efficiency was assessed utilizing customary strains of Staphylococcus aureus and Escherichia coli.
Outcomes and Dialogue
Incorporating CNTs considerably improved the mechanical energy and thermal stability of the PLA-curcumin nanofibers. Tensile testing confirmed that even small additions of CNTs enhanced tensile energy in comparison with pure PLA. Drug launch research confirmed a managed and sustained launch of curcumin, with the speed modulated by CNT focus. This impact was attributed to adjustments in scaffold porosity and microstructure.
Antibacterial assays revealed that CNT-containing composites had a marked inhibitory impact on bacterial development. The PLA-Cur-0.05 % CNT formulation confirmed the best antibacterial exercise, with a 78.95 % discount in microbial development. Whereas curcumin alone confirmed restricted antibacterial efficacy within the PLA matrix, CNTs appeared to help each dispersion and membrane-disruptive mechanisms, contributing to improved outcomes.
Water absorption checks additional supported the composite’s suitability for wound care. Whereas PLA alone exhibited excessive water uptake, the addition of curcumin and CNTs diminished this absorption. A extra average water uptake profile is advantageous for managing exudates with out compromising the mechanical integrity of the dressing.
Conclusion
This research demonstrates the potential of CNT-enhanced PLA-curcumin nanofiber mats as multifunctional wound dressings. The mix of improved mechanical properties, antibacterial exercise, and managed drug launch presents a promising platform for an infection administration and wound therapeutic help. The design leverages nanostructure engineering to beat the constraints of standard supplies and drug supply methods.
Future analysis ought to discover in vivo efficiency, scalability, and additional refinement of the composite formulation. Optimizing element ratios and evaluating long-term biocompatibility will likely be key steps towards medical software.
Journal Reference
Faal M., et al. (2025). Fabrication and analysis of polylactic acid-curcumin containing carbon nanotubes (CNTs) wound dressing utilizing electrospinning methodology with experimental and computational approaches. Scientific Stories. DOI: 10.1038/s41598-025-98393-2, https://www.nature.com/articles/s41598-025-98393-2
