For those who’ve began to consider longevity or perimenopause and that’s taken you down a rabbit gap of dietary supplements, I really feel you. AgelessRX got here on my radar in 2024 after a deep dive on researching LDN. As a result of I used to be able to maintain coaching, however my physique felt completely different and I wanted to determine methods to assist it.
As a result of most runners I work with aren’t in search of shortcuts. They’re already doing the issues:
- coaching persistently
- dialing in vitamin
- prioritizing sleep (or at the very least making an attempt to)
And but… typically one thing nonetheless feels off.
Power dips. Restoration lags. That underlying “blah” feeling that’s onerous to elucidate, however very actual. I used to be discovering this not simply in myself, however in so lots of our runners over 40 that I wished to discover choices. The complement market has an possibility for all the things, however once more I wished one thing with a bit extra proof behind it and I used to be open to being the guinea pig for the group.
I’m so glad I used to be.
What’s AgelessRX?
A particularly essential distinction, AgelessRx isn’t a complement firm. It’s a telehealth platform.
Which means all the things is overseen by U.S.-licensed physicians, it’s HIPAA-compliant, and so they work with compounding pharmacy companions to supply remedies which are sometimes more durable to entry by means of a conventional physician’s workplace.
The objective is actually about making longevity-focused care extra accessible and personalised.
For those who determine to discover it, you’re not simply clicking “add to cart.” There’s a screening course of to find out if one thing is suitable for you, and ongoing check-ins to assist handle dosing alongside the way in which.
They provide a variety of choices—issues like NAD+, LDN, Metformin, GLP-1s, Sermorelin, Rapamycin, B12, and extra. I can’t communicate to all of these, and I received’t fake to. However I can share my expertise with LDN and NAD+, that are those I’ve frolicked researching and testing myself.
And the explanation I even went down this path comes again to what I’m seeing day by day as a coach.
At this level, over 60% of our one-on-one athletes are girls navigating perimenopause or menopause (and sure, loads of males over 40, too). Which implies we’ve had a front-row seat to how shifting hormones can present up in a different way for everybody.
However there are positively patterns.
The commonest issues we hear?
Persistent, random aches.
Sleep disruptions.
And that underlying fatigue that doesn’t fairly match the hassle you’re placing in.
Which lead me to have a look at what can I do past good coaching to raised assist my altering physique (and my athletes!).
How Does it Work
- On-line consumption kind / medical questionnaire
- Doctor critiques and approves (or declines) your prescription
- Remedy ships on to your door from a compounding pharmacy.
- I’ve had no points with pausing once I didn’t want and located it tremendous simple to cancel one subscription once I determined it wasn’t the suitable time for me.
- Word: some states require a video seek the advice of first
- ID verification required
- Subscription primarily based!! That is the one odd criticism from folks, however it’s clearly marked it auto renews and as famous I discovered it tremendous simple to show off all on my own with out calling or utilizing on-line assist.
Low Dose Naltraxone for Aches, Cravings and Mind Fog
Low Dose Naltrexone (LDN) is a a lot smaller dose of a drugs initially utilized in increased doses for different medical situations.
At low doses (sometimes ~1–4.5 mg), it seems to work in a different way, primarily by:
- supporting the physique’s endorphin manufacturing
- modulating the immune system
- serving to cut back irritation
That is the place it will get fascinating for runners.
As a result of after we speak about feeling higher, operating stronger, and recovering effectively… we’re actually speaking about these actual methods.
After I entered perimenopause I went from being an athlete who not often had accidents or greater than a bit twinge right here an there to somebody with random aches on a regular basis. I felt snug beginning hormone substitute remedy and that made a distinction in assuaging the unexplained accidents, however there was nonetheless aches that made no sense.
I did a ton of analysis on LDN and felt like AgelessRX was a dependable place to try it out.
LDN continues to be an rising space of analysis, however there are some promising research, significantly round irritation, ache, and immune response.
- A examine on fibromyalgia discovered that LDN decreased ache and improved temper in individuals
- Analysis revealed in Medical Rheumatology confirmed enhancements in signs for folks with Crohn’s illness and different inflammatory situations
- A assessment in Frontiers in Immunology highlighted LDN’s potential function in regulating the immune system and lowering power irritation
Whereas these aren’t operating particular research, they level to one thing related: when irritation and immune perform enhance, folks are likely to really feel higher total.
And if you really feel higher… you practice higher.
What have been my outcomes?
Some I anticipated and a few I didn’t, however all have been sufficient that I quietly beneficial it to shut pals over the subsequent 12 months and noticed lots of them have large adjustments too.
The factor to recollect is these aren’t prompt in a single day magic outcomes. This isn’t a ache killer, however it’s one thing that for me made a major change in my total feeling.
- Decreased the power irritation, so my random ankle ache or sudden neck ache stopped
- Decreased sugar cravings which was tremendous useful as we don’t course of sugar as effectively with perimenopause
- Improved sleep
- My temper additionally felt elevated
Pals with autoimmune points discovered their physique felt higher and one other with ADHD even discovered it helped them with the mind fog. I’m not calling it a treatment all or a miracle drug. All of us are nonetheless practising good sleep hygiene, hydrating, fueling and understanding.
Nevertheless it felt prefer it was making these items simpler once more.
NAD+ for Power and Mind Fog
After I first began sharing about HRT, one of the fascinating responses I obtained was from girls who stated, “I’m not prepared for that but… however I attempted NAD+ and felt wonderful.”
Power. Temper. Psychological readability.
It saved developing over and over.
So like with LDN, I made a decision to remain open to a brand new concept and take a look at it myself.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in each cell in your physique, and it performs a central function in how we produce vitality on the mobile degree—particularly contained in the mitochondria, that are basically the engines driving all the things out of your exercises to your restoration. Analysis reveals that NAD+ ranges decline as we age, and that drop is tied to adjustments in mitochondrial perform, metabolism, and total mobile well being.
That’s a giant a part of why it’s getting a lot consideration within the longevity area.
There’s additionally rising analysis taking a look at how supporting NAD+ ranges might affect getting old pathways, irritation, and muscle perform. For instance, a current paper in Biochemical and Biophysical Analysis Communications explores how NAD+ precursors may play a job in age-related ailments by supporting mobile restore processes and vitality metabolism.
And in additional utilized physiology, research have proven that restoring NAD+ ranges in getting old muscle can enhance mitochondrial perform, cut back oxidative stress, and even improve endurance and restoration in preclinical fashions.
So when folks say they “really feel higher,” there may be at the very least a physiological speculation behind it.
I attempted NAD+ as a nasal spray after listening to all these optimistic experiences. And for me? It was… nice.
Not unhealthy, not life-changing. I didn’t discover a dramatic shift in vitality or restoration, and finally determined it wasn’t one thing I wished to maintain investing in long-term. The upside: it was simple to strive, and simply as simple to cease.
Ought to You Strive LDN or NAD+?
And I believe that final level is a extremely essential a part of this dialog.
As a result of whereas the science is promising, it’s nonetheless evolving. Lots of the strongest knowledge shouldn’t be in runners navigating real-life coaching, stress, sleep, and hormones .
However that doesn’t imply it’s not price exploring.
It simply means we method it the identical manner we method coaching: with curiosity, context, and a willingness to regulate.
For some, they may be a significant lever for vitality and restoration. For others, it may be impartial.
We’re on the cusp of a time the place abruptly getting old, perimenopause and menopause are being studied, mentioned extra overtly and considered with options. BUT we don’t have all of the solutions but and I can completely say that the expertise varies by particular person.
So I’m simply hopeful that by sharing extra and speaking about it, I give others data I want I’d had on day one in all realizing one thing is completely different and never understanding methods to resolve it.
This isn’t a sponsored assessment, however my expertise with LDN was so good that after a 12 months I reached out to AgelessRX.com as a result of I actually wished to share. They have been sort sufficient to supply a reduction code for 10% any first buy.
Ageless RX Low cost Code: RUNTOTHEFINISH
Personally I belief them and have favored all of the communication and repair that not simply I’ve obtained, however what I’ve seen in pals who’ve tried it.
What to learn subsequent?
